GMB ONGOING PROJECTS of Prof. Marins group

Exploring the activity of the Sp1 transcription factor associated with the mesenchymal epithelial transition as a therapeutic target of osteossarcoma (Major Project)
Related projects

Inhibitors of HDAC1 / SP1 binding for the development of anticancer drugs (Flávia)

Chemical and genetic modulation of the mesenchymal epithelial transition pathway in osteosarcoma cell lines (Vânia)

Effect of α, β-unsaturated carbonyl compounds on the expression of DNA repair pathways in osteosarcoma cell lines (Alessandra / Stephany / Isabela)

The role of the DNAJB1 chaperone in the biological activity of polyphenols in human osteosarcoma cell lines (Stephany / Alesandra / Isabela)

Establishment of a double-hybrid bacterial system for drug screening with inhibitory activity of the protein-protein interaction related to EMT (Giovana / Vânia / Flávia)
           
Development, characterization and evaluation of anticancer activity of polyvinyl alcohol hydrogel-based nanocarriers associated with doxorubicin, cisplatin and α, β-unsaturated carbonyl compounds (Major Project)
Related projects

Development of anticancer drug delivery vehicles composed of PVA nanoparticles combined with chalcones and doxorubicin (Viviane)

Establishment of elctrospray system for the production of anticancer drug nanocarriers (Carlos / Miriam / Viviane)
        
Inhibitors of adipogenesis and identification of biomarkers

Screening of compounds inhibiting adipogenesis in 3t3-L1 cells and expression of GDF15 (Flávia / Isabela / Vânia)